S-Acetyl-L-Glutathione
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CAS No.: 3054-47-5
TYPE: JP GRADE & USP GRADE
BRAND: ZNCBIO
MOQ: 20 KGS
Introduction of S-Acetyl-L-Glutathione
S-Acetyl-L-Glutathione is a highly active derivative of natural reduced glutathione that has undergone acetylation modification. It is produced through advanced biological fermentation and synthesis processes, with high purity of components.
It appears as a white or off-white fine crystalline powder, has good water solubility, stable physical and chemical properties, is resistant to acids and alkalis, and is an antioxidant. It can effectively resist the decomposition by human gastric acid and digestive enzymes, addressing the shortcomings of low oral absorption rate and easy inactivation of ordinary glutathione. It can be efficiently absorbed by the intestines and exert its effects deeply within cells.
It is a potent natural antioxidant substance that can eliminate excess free radicals in the body, alleviate oxidative stress damage, assist in liver metabolism and detoxification, and repair liver damage. At the same time, it can inhibit melanin deposition, improve skin dullness and aging, and also regulate the body’s immunity and maintain normal physiological functions of cells. It is widely used in functional dietary supplements, health nutrition products, and high-end skincare cosmetics.
Basic Information of S-Acetyl-L-Glutathione
| Items | Specification | Measured Values |
|---|---|---|
| Appearance | Appearance: White crystalline powder. Lot specific. | Lot specific. |
| Identification by NM | Confirms to the structure | Lot specific. |
| Identification by MAS | Confirms to the structure | Lot specific. |
| Purity | >95% | Lot specific. |
| Mol. Weight | 349.36 g/mol. | Lot specific. |
| Melting point | 195°C. | Lot specific. |
| Boiling Point | 770.2°C. | Lot specific. |
| Density | 1.436 g/cm3. | Lot specific. |
| Solubility | Soluble in water | Lot specific. |
| Storage | Store at ambient temperature | Lot specific. |
Function of S-Acetyl-L-Glutathione
S-acetyl-L-glutathione is a stable modified form of reduced glutathione, which overcomes the shortcomings of ordinary glutathione, such as being easily decomposed by gastric acid and having poor absorption. It can completely enter human cells and be converted into active glutathione, providing more comprehensive and long-lasting effects. The core functions are as follows:
1. Super strong antioxidant, combating systemic oxidative damage
As the core endogenous antioxidant of the human body, it can efficiently eliminate free radicals, peroxides, and metabolic toxins, reducing chronic damage to cells and organs caused by oxidative stress; at the same time, it collaborates in the regeneration of antioxidant substances such as vitamin C and vitamin E, constructing a systemic antioxidant barrier, delaying cell aging, and slowing down the aging process of the body.
2. Deep liver protection and detoxification, repairing liver function
Participating in the second-stage detoxification metabolism of the liver, it efficiently combines and metabolizes harmful substances such as alcohol, drug residues, heavy metals, and chemical additives, accelerating the elimination of toxins; reducing liver damage caused by alcohol, staying up late, high-fat diet, and chemical substances, improving liver metabolic pressure, assisting in regulating fatty liver and abnormal liver enzymes, and maintaining normal physiological operation of the liver.
3. Whitening and brightening skin, improving skin problems
Inhibiting tyrosinase activity, reducing the generation and deposition of melanin from the source, fading spots, acne marks, and dull yellowish complexion; repairing oxidative damage caused by ultraviolet rays, external stimuli, and skin oxidation, soothing inflammation, improving roughness and dullness, evenly distributing skin color, enhancing transparency, and simultaneously strengthening skin barrier resilience, resisting photoaging, and reducing the formation of fine lines.
4. Regulating immunity, enhancing body resistance
Empowering immune cells to normal proliferation and active operation, enhancing the defense ability of immune cells, reducing the risk of external pathogen invasion; balancing the inflammatory response in the body, reducing chronic low-level inflammation, suitable for long-term regulation of individuals with weak constitution, prone to fatigue, and low immunity.
5. Anti-fatigue, improving metabolism and body condition
Improving cellular energy metabolism, alleviating long-term staying up late, high-pressure work, excessive exercise-induced physical fatigue and mental lethargy; regulating the overall metabolism, reducing chronic wear and tear of the body, enhancing energy and physical endurance, maintaining body homeostasis.
6. Nervous system and deep body repair
It can penetrate the blood-brain barrier, neutralizing brain oxidative toxins, soothing nervous tension, assisting in maintaining the health of the nervous system; protecting cells of organs such as the heart, lungs, and digestive tract, reducing the risk of chronic metabolic problems, and taking care of the overall functional maintenance.
7. Gentle and easily absorbed, wide application range
Chemical and physical properties are stable, resistant to gastric acid and digestive enzyme destruction, the oral bioavailability is much higher than that of ordinary glutathione, gentle and non-irritating, suitable for multi-scenario applications such as dietary supplements, functional foods, and skin care raw materials, with high safety for long-term supplementation.
Application of S-Acetyl-L-Glutathione
S-acetyl-L-glutathione boasts core advantages such as strong stability, resistance to stomach acid, high absorption rate, long-lasting activity, and excellent safety. Compared to ordinary reduced glutathione, it has a wider application range and is suitable for multiple mainstream fields including health supplements, cosmetics, medicine, and functional foods. The specific breakdown is as follows:
1. Functional dietary supplements sector
This is the most core and largest application scenario. Relying on excellent oral bioavailability, it is often formulated into capsules, tablets, powders, oral liquids, etc. It mainly targets overall antioxidant, liver care, daily detoxification, and improvement of sub-health conditions, targeting people who stay up late, long-term drinkers, people with high-pressure office work, and those with weak metabolism. It is also often used in overall whitening, internal skin care products, as a core raw material for high-end whitening and anti-aging formulas, combined with antioxidant components for compound use.
2. Skin care cosmetics and personal care sector
As a high-end functional skin care raw material, it is widely added to essences, creams, solutions, whitening masks, body care products. Through antioxidation, inhibition of melanin production, and removal of skin free radicals, it improves skin dullness, yellowish complexion, pigmentation, and photoaging problems; it also alleviates oxidative damage caused by external environment and ultraviolet rays on the skin, repairs fragile skin foundation, balances skin micro-inflammation, and combines brightening, evening skin tone, and anti-aging effects. It is a popular raw material for luxury skincare lines and cross-border cosmetics.
3. Health care food industry
It is compliantly applied in high-end health foods, customized nutrition formulas, and special dietary foods. Special formulas are developed for chronic oxidative stress, immune regulation, liver and kidney care, and post-operative body repair; it is suitable for nutrition enhancement for middle-aged and elderly care, post-operative recovery period conditioning, and long-term toxin-exposed populations. It is gentle and suitable for long-term daily dietary supplementation, has low side effects, and strong compatibility. It can be combined with amino acids, vitamins, and plant extracts for compound use.
4. Medical and large-scale health research sector
It is widely used in clinical auxiliary regulation and can be used to improve problems such as drug-induced liver injury and abnormal metabolism of chemical toxins. It is also used in auxiliary research on chronic diseases related to oxidative stress, cell repair pharmacological research; due to its ability to penetrate cell membranes and high stability, it becomes an important active raw material in biomedical and cell biology research, with its application value continuously expanding.
5. Sports nutrition and weight management products
It is applied in sports supplements, body performance management, and metabolic regulation products. It helps remove a large number of free radicals produced by intense exercise, reduces muscle oxidative damage and post-exercise soreness, and accelerates physical recovery; it regulates the body’s metabolic level, alleviates physical fatigue caused by long-term exercise and high-intensity training, maintains the body’s oxidative balance, and is suitable for professional sports nutrition formulas.
6. Cross-border high-end raw materials and customized formula market
It has strong demand in overseas markets such as Europe, Asia, and the Americas. It is a benchmark raw material for cross-border health supplements and imported functional foods. Due to its stable physical and chemical properties, long storage period, and good processing tolerance, it is suitable for large-scale production and long-distance transportation, facilitating industrial batch feeding, high-temperature processing, and long-term storage, and is suitable for global raw material trade, customized formula outsourcing, and OEM/ODM industrial production.
The Mechanism Of Action Of S-acetyl-L-glutathione
1. Structural Modification: Addressing the Core Defects of Common Glutathione
The active sulfhydryl group (-SH) of common reduced glutathione (GSH) is extremely unstable and is easily decomposed and destroyed by gastric acid and digestive enzymes after oral administration, making it difficult to be absorbed and having a very low biological utilization rate. S – Acetyl – L – Glutathione introduces an acetyl group on the sulfhydryl group of cysteine, forming a molecular protective structure:
Shielding the easily oxidized active sulfhydryl group, resistant to gastric acid and digestive enzymes, and not easily degraded in the gastrointestinal tract;
Enhancing lipid solubility and cell membrane penetration, allowing it to be completely absorbed through the intestinal epithelium and enter the bloodstream;
After entering human cells, it is specifically hydrolyzed by intracellular esterases, removing the acetyl group and reverts to the natural active reduced GSH, exerting physiological functions in situ.
2. Core Antioxidant Mechanism
Directly eliminating free radicals
As an essential endogenous antioxidant, it directly neutralizes reactive oxygen species, peroxides, and lipid oxidation products, blocking the oxidative chain reaction, and reducing oxidative damage to cellular lipids, proteins, and DNA.
Regenerating the antioxidant system
Cycling the reduction of exogenous antioxidants such as vitamin C, vitamin E, and coenzyme Q10 to amplify the overall antioxidant capacity and build a systemic antioxidant protection network.
Maintaining the balance of cellular redox potential
Stabilizing the intracellular redox potential, inhibiting chronic oxidative stress, and reducing chronic inflammation and causes of cell aging.
3. Liver Detoxification Metabolic Mechanism
Participating in Phase II detoxification reactions
The core pathway of liver detoxification, combining with heavy metals, alcohol metabolites, drug toxins, environmental toxins, and carcinogens, converting them into non-toxic water-soluble complexes, accelerating their excretion through bile and urine.
Repairing liver cells
Reducing chemical, alcoholic, and drug-induced liver damage, inhibiting liver cell apoptosis, protecting the integrity of the liver cell membrane, and improving liver metabolic function.
4. Whitening, Anti-black, and Skin Repair Mechanism
Inhibiting melanin synthesis
Down-regulating tyrosinase activity, blocking the key pathway of melanin synthesis, reducing excessive secretion of melanin by melanocytes, and fading pigmentation, dullness, and discoloration.
Anti-inflammatory repair barrier
Inhibiting excessive oxidative inflammatory responses in the skin, soothing skin damage caused by ultraviolet rays, external stimuli, and repairing the keratin barrier, delaying photoaging.
5. Immune Regulation and Body Repair Mechanism
Activating immune cells
Maintaining the normal proliferation and activity of immune cells such as lymphocytes and macrophages, enhancing the body’s defense ability.
Cross-organ protection
It can penetrate the blood-brain barrier and cell membranes, protecting nerve cells and organ cells, reducing the risk of oxidative damage to multiple organs throughout the body.
6. Metabolic Anti-fatigue Mechanism
Reducing metabolic toxins and oxidative accumulation produced by high-intensity metabolism and long-term stay up late， improving mitochondrial energy metabolism， alleviating fatigue and sub-health conditions.
Contact Details
SHANGHAI ZNCBIO
Precautions for S-Acetyl-L-Glutathione
1. Contraindications for Consumption and Administration
People with allergies should avoid use.
Those who are allergic to glutathione-based substances, acetylated derivatives, or the raw materials of this product must not use it. It may cause allergic reactions such as skin itching, rashes, swelling, respiratory discomfort, etc.
Special populations should use with caution.
Pregnant women, lactating women, infants, and people with extremely weak constitutions should use it under the guidance of a professional physician or nutritionist in limited quantities. It is not recommended to take it for a long time on your own.
Patients with severe diseases should follow the doctor’s advice.
Patients with severe liver diseases, kidney diseases, autoimmune diseases, serious chronic diseases, and cancer patients should not blindly supplement without consulting a doctor. They should use it in accordance with the doctor’s advice to avoid interfering with body metabolism and disease regulation.
2. Attention to Drug Interactions
Avoid taking with chemotherapy drugs, immunosuppressants, anticoagulant drugs. This product can regulate the body’s oxidation and immune levels, which may affect the efficacy or increase the body’s metabolic burden.
People taking prescription drugs, liver-protecting drugs, or hormone products for a long time should consume separately at least 2 hours apart to prevent the interaction of components and reduce absorption efficiency.
3. Dosage Specifications and Adverse Reactions
Do not over-supplement.
For daily health care, the dosage should be controlled within a reasonable range. Long-term high-dose intake may cause mild gastrointestinal discomfort, such as abdominal distension, acid reflux, diarrhea, nausea, etc.
If any discomfort occurs during use, stop using immediately and seek medical attention for examination.
4. Storage and Stability of Raw Materials
The powder of this product is prone to moisture absorption, afraid of high temperature, and afraid of strong light. It should be sealed and stored in a cool, dry, dark, and low-temperature environment. It is strictly prohibited to be exposed to dampness and direct sunlight to prevent the oxidation and color change of raw materials, the degradation of active ingredients, and the decrease in content.
Use it as soon as possible after opening to avoid long-term exposure. Avoid microbial contamination, caking, and deterioration to ensure product quality and usage safety.
5. Production and Processing Application Attention (Industrial Raw Materials End)
Compliance Restrictions: Do not compound with acidic, alkaline, or oxidizing raw materials, as it will destroy the acetylation structure and lead to the loss of activity.
Processing Conditions: Avoid long-term high-temperature and high-pressure processing. High temperature will cause component decomposition and reduce the product’s efficacy and activity.
Compliance Combination: When combined with vitamin C, glutathione, and plant antioxidant extracts, it can synergistically enhance efficacy. However, the ratio should be controlled to prevent chemical property conflicts.
6. Other Daily Considerations
This product is a functional raw material / dietary supplement raw material. It cannot replace medicine and has no therapeutic effect on diseases. It cannot be used for disease treatment.
People with disrupted sleep patterns and long-term alcohol abuse should not rely on this product to compensate for damage. It can only be used as an auxiliary adjustment. Healthy sleep patterns and dietary habits are the basis.
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Shanghai ZNC Biotechnology Co., Ltd.(ZNCBIO) is a supplier of various chemicals and packaging materials. In addition to S-Acetyl-L-Glutathione、Glutathione for Injection、Oxidized Glutatione， it can also provide you with products in many fields such as nutritional supplements, food additives, APIs, cosmetics and minerals.
