1) Basic information

Product Name: Berberine HCl (Berberine Hydrochloride)

CAS Number: 633-65-8

Molecular Formula: C₂₀H₁₈NO₄·HCl

Purity: ≥ 97% (HPLC)

Appearance: Bright yellow to yellow powder

Storage: Store in a cool, dry place away from direct sunlight

Shelf Life: 24 months when stored properly

2) Product Description

Berberine HCl is a bioactive compound extracted from plants such as goldenseal, barberry, and Oregon grape. It has been used for centuries in traditional medicine for its wide range of health benefits. Modern research supports its effectiveness in promoting metabolic health, cardiovascular function, and immune support.

3) Function and Usage

1. Supports Healthy Glucose Metabolism & Blood Sugar Regulation
Berberine HCl has been extensively studied for its ability to activate AMP-activated protein kinase (AMPK), a crucial enzyme involved in cellular energy homeostasis. By enhancing insulin sensitivity and promoting glucose uptake in cells, Berberine HCl helps maintain balanced blood sugar levels within a normal range. Clinical studies suggest it may be as effective as some conventional glucose-lowering agents, making it a valuable supplement for metabolic health support.

2. Promotes Cardiovascular Health & Healthy Lipid Profiles
Research indicates that Berberine HCl supports cardiovascular function by modulating lipid metabolism. It helps maintain healthy LDL cholesterol, HDL cholesterol, and triglyceride levels by inhibiting PCSK9 and enhancing LDL receptor expression in the liver. Additionally, its vasodilatory properties contribute to optimal blood pressure regulation, further supporting heart health.

3. Enhances Gut Health & Microbiome Balance
Berberine HCl exhibits broad-spectrum antimicrobial activity against pathogens in the gastrointestinal tract while sparing beneficial bacteria. It helps maintain a healthy gut microbiome by inhibiting the overgrowth of harmful bacteria and fungi, supporting digestive comfort, intestinal barrier integrity, and immune function.

4. Antioxidant & Anti-Inflammatory Effects
As a natural alkaloid, Berberine HCl demonstrates potent antioxidant properties, scavenging free radicals and reducing oxidative stress. It also modulates key inflammatory pathways (e.g., NF-κB and MAPK), helping to alleviate chronic low-grade inflammation, which is linked to various metabolic and age-related conditions.

5. Supports Weight Management & Metabolic Efficiency
Berberine HCl aids in healthy weight management by improving metabolic flexibility, enhancing mitochondrial function, and promoting fat utilization for energy. Studies suggest it may help reduce visceral fat accumulation and support a balanced appetite, making it a useful adjunct for weight control strategies.

6. Liver Health & Detoxification Support
By activating AMPK and Nrf2 pathways, Berberine HCl promotes liver detoxification and protects against oxidative damage. It supports optimal bile flow, liver enzyme balance, and metabolic waste clearance, contributing to overall hepatic function.

7. Immune System Modulation
Berberine HCl exhibits immunomodulatory effects, enhancing innate and adaptive immune responses. Its antimicrobial and anti-inflammatory properties make it beneficial for maintaining immune resilience, particularly in supporting respiratory and gastrointestinal defenses.

4) Application

Dietary Supplements (capsules, tablets, powders)

Functional Foods & Beverages

Traditional Herbal Formulas

Research & Pharmaceutical Development

5) Where to buy Berberine HCL?
Shanghai ZNCBIO is a supplier for many chemicals and packing materials. Products cover many fields: such as Nutritional, Food additives, APIs, Cosmetics and minerals. You could get professional and customized service for any inquiry within 12 hours from ZNCBIO.

6) Package: 25KG/DRUM

7) Storage: Store in a cool, dark, and dry place.

8) Delivery: Common goods, no transportation restrictions.