MK-677 Ibutamoren Mesylate

IbutamorenMesylateMK-677

1. Product Name:  Ibutamoren Mesylate

2. Synonyms: MK-677

3. CAS NO.: 159752-10-0

4. Files Support: HPLC graph, COA, MSDS


Ibutamoren (INN) (developmental code names MK-677, MK-0677, L-163,191; former tentative brand name Oratrope) is a potent, long-acting, orally-active, selective, and non-peptide agonist of the ghrelin receptor and a growth hormone secretagogue, mimicking the growth hormone (GH)-stimulating action of the endogenous hormone ghrelin. It has been shown to increase the secretion of several hormones including GH and insulin-like growth factor 1 (IGF-1) and produces sustained increases in the plasma levels of these hormones without affecting cortisol levels.

Ibutamoren has been shown to sustain activation of the GH–IGF-1 axis and to increase lean body mass with no change in total fat mass or visceral fat. It is under investigation as a potential treatment for reduced levels of these hormones, such as in children or elderly adults with growth hormone deficiency,[3][9][10][11] and human studies have shown it to increase both muscle mass and bone mineral density, making it a promising potential therapy for the treatment of frailty in the elderly.As of June 2017, ibutamoren is in the preclinical stage of development for growth hormone deficiency.


Function: 

Inhibits the signaling of somatostatin receptors
Slows down the activity of somastostatin in the system
Improves somatotroph signaling in growth hormone releasing hormones (GHRH)
Amplifies and increases the overall production and release of GHRH


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HMB CA|Hordenine hydrochloride|Huperzine A|Daidzein



Product Name:

Calcium β-hydroxy β-methylbutyrate (HMB-Ca)

CAS NO.:

135236-72-5


Shelf Life:

2 years

ITEMS

SPECIFICATION

Appearance

White Fine Powder

HMB

84.0% Min

Calcium

16% Max

Total Content

99.0% Min

Particle Size

100% Pass 80 Mesh

Loss on drying

7.0% Max

Heavy metals

10 ppm Max

Pb

3 ppm Max

As

1 ppm Max

Hg

0.1 ppm Max

Cd

1 ppm Max

Total Plate Count

1000 cfu/g Max

Yeast & Mold

100 cfu/g Max

E-Coli

Negative

Salmonella

Negative

label: MK-677